Thrombosis with thrombocytopenia syndrome (TTS) is a condition where blood clots form in the brain or other parts of the body, resulting in low platelet counts. Platelets help blood clot and prevent excessive bleeding. The risk of TTS is higher in individuals under 60 years old and can occur in various areas of the body.
Scientists are still studying how TTS forms, with some experts suggesting it may be similar to heparin-induced thrombocytopenia (HIT), which is a rare reaction to the anticoagulant drug heparin. Symptoms can include severe headaches, vision problems, seizures, difficulty speaking or chest pain, abdominal pain, shortness of breath or swelling.
Currently, there are no known medical conditions that increase the risk of developing TTS after vaccination. Younger people and women may experience more severe symptoms, and the risk of TTS after the second vaccine dose is lower than after the first. Diagnosing TTS involves blood tests and CT scans, and treatment often includes anticoagulants, IVIG for blood transfusions containing antibodies and high doses of prednisone.
In some cases, immediate hospitalization may be necessary for treatment if a blood clot in the brain is suspected. It’s important to seek medical attention promptly if TTS is suspected.