Dr. Nguyen Thi Mong Diep and her team of researchers at Quy Nhon University have made significant advancements in reproductive support technology by developing two new recombinant gonadotropin hormones, hFSH (human Follicle Stimulating Hormone) and eCG (equine Chorionic Gonadotropin). These hormones have shown promising results in improving fertility for both humans and animals.
The team’s research was funded by Vingroup Innovation Fund (VINIF) in November 2020, and they successfully launched the hormones by April 2024. The production process involved design, plasmid amplification, expression on cells, purification, biological activity analysis in the laboratory, and testing on mammalian models.
Natural gonadotropin hormones have been used for a long time in treating infertility in humans and animals, but production and supply challenges exist due to hygiene and ethical issues. Associate Professor Dr. Nguyen Thi Mong Diep’s team aimed to address these challenges by developing recombinant gonadotropin hormones as a viable alternative. These hormones offer a more sustainable and cost-effective solution for infertility treatment in humans and reproduction control in animals.
The development of single-chain recombinant hormones hFSH and eCG has the potential to revolutionize assisted reproductive techniques by providing a more effective and accessible solution. The research conducted by Dr. Nguyen Thi Mong Diep’s team has high commercialization potential and can contribute to advancing Vietnam’s biotechnology sector.
Dr. Huynh Gia Bao, an expert in IVF techniques, hopes that the research project on recombinant hormones will help improve accessibility and reduce treatment costs for Vietnamese patients, especially those in remote areas. With the potential for practical applications implemented by the Vietnamese people, this research project could expand opportunities for infertile couples to have children.
Associate Professor Dr. Nguyen Thi Mong Diep is actively involved in research collaborations with the French National Institute for Research on Agriculture, Food, and the Environment (INRAe). Her goal is to establish a laboratory at Quy Nhon University to further research and education in the field of biotechnology. Dr. Nguyen Thi Mong Diep’s accomplishments have been recognized internationally with her meeting professor standards in France in 2024 and being ranked among the top 3 candidates for specialized positions in Physiology, Biochemistry, and Organismal biology.
Overall, Associate Professor Dr. Nguyen Thi Mong Diep’s work represents a significant advancement in reproductive support technology with the potential to benefit both human
