Beyond 2D: How Emulate’s Organ-Chips are Revolutionizing Disease Research and Drug Discovery

For decades, scientists have been using 2D cell culture to study human biology and have made significant advancements in the field. However, recent research has shown that the artificial nature of 2D cell culture, which includes the use of cancerous cell lines, static microenvironments, and limited cellular complexity, restricts its ability to accurately model human diseases and predict human reactions to drug candidates.

To overcome these limitations, Organ-Chips have been developed as an innovative cell culture technology that offers a more human-relevant platform for disease research and drug discovery and development. These advanced in vitro models replicate the microenvironment that cells experience within the human body, providing a more authentic representation of human responses compared to traditional 2D cell culture.

In a webinar led by Luke Dimasi, Senior Director of Product Management at Emulate, an overview of the Emulate Organ-on-a-Chip technology is provided. The webinar explores the advantages of Organ-Chips over 2D cell culture and offers data-driven examples demonstrating their enhanced physiological relevance. According to Dimasi, “Organ-Chips provide a more accurate representation of human biology than traditional 2D cell culture.” By replicating the complex interactions between cells and their environment in a more realistic way, Organ-Chips offer a promising tool for disease research and drug development.