During the process of apoptosis, dying cancer cells undergo a self-destruction that results in shrinking, the release of membrane fragments, and their engulfment by immune cells called phagocytes. These phagocytes break down the dead cancer cells into smaller components that can be recycled and reused by other cells in the body. However, some cases of cancer cell death may not result in complete destruction, leading to inflammation and promoting cancer growth through a phenomenon known as the Révész effect.
Research has shown that when the nucleus of dying cancer cells swells and bursts, it can accelerate metastasis or the spread of cancer cells beyond the original tumor site. This complex interplay between tumor cell death and cancer progression highlights the need for ongoing research to develop more effective treatments. For example, a study suggested that a molecule derived from omega-3, called resolvin, could help reduce inflammation and promote clearance of cellular debris from dead cancer cells.
As our understanding of cancer biology deepens, researchers hope to uncover new strategies for combating cancer and improving treatment outcomes. By studying the intricate processes involved in cancer cell death and its implications for cancer progression, scientists aim to develop more targeted and effective therapies in the fight against this complex disease.
