Breaking News

SPACELINE Present Awareness Lists are distributed by means of listserv and are obtainable on the NASA Job Book web site at

Please send any correspondence to Shawna Byrd, SPACELINE Present Awareness Senior Editor, [email protected].

Get in touch with for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an report that has lately published or will publish in the upcoming weeks inside a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your report to the e-mail address described above. Articles received by Wednesday will seem inside that week’s list—articles received soon after Wednesday will seem the following week.

Papers deriving from NASA assistance:


Freeborn TJ, Critcher S, Hooper G.

Segmental tissue resistance of healthful young adults in the course of 4 hours of six-degree head-down-tilt positioning.

Sensors (Basel). 2023 Mar 323(five):2793.

Note: Head-down tilt study. This report might be obtained on the web with no charge.

Journal Influence Element: 3.847

Funding: “This study was supported by funding from the Alabama NASA EPSCoR FY19 Analysis Infrastructure Improvement, grant 80NSSC19M0051.”


Lawrence LM, Salary RR, Miller V, Valluri A, Denning KL, Case-Perry S, Abdelgaber K, Smith S, Claudio PP, Day JB.Osteoregenerative possible of 3D-printed poly ε-caprolactone tissue scaffolds in vitro utilizing minimally manipulative expansion of key human bone marrow stem cells.

Int J Mol Sci. 2023 Mar 324(five):4940.

Note: This report might be obtained on the web with no charge.

Journal Influence Element: 6.208

Funding: “The present research had been partially funded by a Marshall University translational study award (to P.P.C.) In addition, this study function was partially funded by the NASA Established Plan to Stimulate Competitive Analysis (EPSCoR)—Rapid Response Analysis, Grant #80NSSC22M0249 (to R.S.).”


Flatt AJ, Peleckis AJ, Dalton-Bakes C, Nguyen HL, Ilany S, Matus A, Malone SK, Goel N, Jang S, Weimer J, Lee I, Rickels MR.

Automated insulin delivery for hypoglycemia avoidance and glucose counterregulation in lengthy-standing variety 1 diabetes with hypoglycemia unawareness.

Diabetes Technol Ther. 2023 Feb 24. On the web ahead of print.

PI: N. Goel

Journal Influence Element: 7.337

Funding: “This function was supported by Public Wellness Service study grants R01 DK091331 (to M.R.R.), UL1 TR001878 (University of Pennsylvania Center for Human Phenomic Science), P30 DK19525 (University of Pennsylvania Diabetes Analysis Center), K99NR017416 (to S.K.M.), and R01 DK11788 (to N.G.) National Aeronautics and Space Administration (NASA) grants NNX14AN49G and 80NSSC20K0243 (to N.G.) Pennsylvania Division of Wellness grant SAP 4100079750 (to I.L.) the Charles B. Humpton, Jr. Endowed Fellowship in Diabetes Analysis (to A.J.F.) and the Human Metabolism Resource of the University of Pennsylvania Institute for Diabetes, Obesity &amp Metabolism. Medtronic supplied discounted 670G insulin pumps and glucose monitoring devices for the study via investigator-initiated grant NERP16-015 (to M.R.R.).”


Mogul R, Miller DR, Ramos B, Lalla SJ.

Metabolomic and cultivation insights into the tolerance of the spacecraft-linked Acinetobacter toward Kleenol 30, a cleanroom floor detergent.

Front Microbiol. 2023 Mar 614:1090740.

Note: This report is aspect of Analysis Subject “The Influence of the Space Atmosphere on Microbial Development and Behavior” ( The Analysis Subject also incorporates articles from preceding Present Awareness List #1,009,, and Extra articles will be forthcoming and might be identified in the hyperlink to the Analysis Subject. This report might be obtained on the web with no charge.

Journal Influence Element: 6.064

Funding: “This function was supported by a grant (NNH18ZDA001N) from the Planetary Protection Analysis element of the National Aeronautics and Space Administration (NASA) Analysis Possibilities in Space and Earth Sciences system.”


Tyson TL, Flynn-Evans EE, Stone LS.

Differential saccade-pursuit coordination below sleep loss and low-dose alcohol.

Front Neurosci. 2023 Feb 1616:1067722.

Note: This report appeared in final week’s Present Awareness list and it is appearing once more to incorporate the create-up of the report from author L.S. Stone: “This study demonstrates that eye-movement-primarily based functionality metrics (oculometrics) are sensitive sufficient to detect modest deficits and certain sufficient to distinguish possible causes. Especially, low-dose alcohol (&lt .05% BAC) benefits in impairment of the cortically controlled pursuit program whilst sleep loss (24 hours awake) impacts cortical, midbrain, and brainstem regions that handle each pursuit and the saccadic backup program. Oculometrics also showed that caffeine largely mitigates pursuit deficits from sleep loss but does not restore regular saccades. These findings validate the possible use of oculometrics for the detection/diagnosis of mild neural impairment in operational settings and the assessment of countermeasure efficacy.” This report might be obtained on the web with no charge.

Journal Influence Element: 5.152

Funding: “This study was supported by the Workplace of Naval Analysis (ONR), NASA’s Human Analysis Plan (HRP), and Ames Center Innovation Fund (CIF).”


Other papers of interest:


Kuldavletova O, Navarro Morales DC, Quarck G, Denise P, Clément G.

Spaceflight alters reaction time and duration judgment of astronauts.

Front Physiol. 2023 Mar 1714:1141078.

Note: ISS benefits. This report is aspect of Analysis Subject “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (—volume-ii#overview). Extra articles will be forthcoming and might be identified in the hyperlink to the Analysis Subject. This report might be obtained on the web with no charge.


Capri M, Conte M, Ciurca E, Pirazzini C, Garagnani P, Santoro A, Longo F, Salvioli S, Lau P, Moeller R, Jordan J, Illig T, Villanueva MM, Gruber M, Bürkle A, Franceschi C, Rittweger J.

Extended-term human spaceflight and inflammaging: Does it market aging?

Ageing Res Rev. 2023 Mar 12101909. Overview.

Note: From the abstract: “Spaceflight and its linked stressors, such as microgravity, radiation exposure, confinement, circadian derailment, and disruptive workloads represent an unprecedented variety of exposome that is totally novel from an evolutionary stand point. Inside this point of view, we aimed to assessment the effects of prolonged spaceflight on immune-neuroendocrine systems, brain and brain-gut axis, cardiovascular program and musculoskeletal apparatus, highlighting in certain the similarities with an accelerated aging procedure.”


Ghosh D, Verma E, Gershman S, Anderson T, Kumar Ghosh R, Peter M.

Central nervous program in the course of human spaceflight missions to Mars. A meta-evaluation.

Int J Med Sci Clin Invent. 2023 Jan 1510(01):6411-50.


Note: From the abstract: “The benefits of extra than 50 years of space-associated neuroscience research on persons and animals subjected to spaceflight or settings that are comparable to spaceflight are reviewed in this report, along with their implications and the future function necessary to guarantee profitable Mars missions.” This report might be obtained on the web with no charge.


Ghosh D, Verma E, Kumar Ghosh R, Gershman S, Anderson T, Peter M.

Challenges and possibilities for neuroscience in the context of spaceflight and the central nervous program.

Int J Med Sci Clin Invent. 2023 Jan 1510(01):6397-410.


Note: From the report: “We give a summary of what is presently recognized about the effect of microgravity on the central nervous program (CNS), each in human and cellular models, primarily based on actual spaceflight and parabolic flight investigations as effectively as ground-primarily based procedures suitable for microgravity-primarily based study. On top of that, we investigate the effect of microgravity on the biology of tumor cells in this assessment, concentrating on brain tumor cells, in order to give a fresh point of view on the study of cancer and somewhat novel therapeutic approaches.” This report might be obtained on the web with no charge.


Marfia G, Guarnaccia L, Navone SE, Ampollini A, Balsamo M, Benelli F, Gaudino C, Garzia E, Fratocchi C, Di Murro C, Ligarotti GK, Campanella C, Landolfi A, Perelli P, Locatelli M, Ciniglio Appiani G.

Microgravity and the intervertebral disc: The effect of space circumstances on the biomechanics of the spine.

Front Physiol. 2023 Mar 1414:1124991. Overview.

Note: From the report: “In the present function, the mechanisms of disc degeneration, the circumstances of microgravity, and their association have been discussed in order to recognize doable molecular mechanisms underlying disc degeneration and the associated clinical manifestations in order to create a model of prevention to preserve overall health and functionality of air- and space-travelers. The concentrate on microgravity also enables the improvement of new proofs of idea with possible therapeutic implications.” This report might be obtained on the web with no charge.


Thoolen SJJ, Kuypers M.

External hemorrhage handle procedures for human space exploration: Lessons from the battlefield.

Wilderness Environ Med. 2023 Mar 9. Overview. On the web ahead of print.


Aventaggiato M, Barreca F, Vitiello L, Vespa S, Valente S, Rotili D, Mai A, Lotti LV, Sansone L, Russo MA, Bizzarri M, Ferretti E, Tafani M.

Part of SIRT3 in microgravity response: A new player in muscle tissue recovery.

Cells. 2023 Feb 2212(five):691.

Note: A rotary cell culture program was applied in this study. This report and the report beneath (Dubayle et al.) are aspect of Specific Concern “New Insights into Microgravity and Space Biology” ( The Specific Concern also incorporates articles from preceding Present Awareness Lists #1,028 #1,032 Extra articles will be forthcoming and might be identified in the hyperlink to the Specific Concern. This report might be obtained on the web with no charge.


Dubayle D, Vanden-Bossche A, Peixoto T, Morel JL.

Hypergravity increases blood-brain barrier permeability to fluorescent dextran and antisense oligonucleotide in mice.

Cells. 2023 Feb 2412(five).

Note: This report and the report above (Aventaggiato et al.) are aspect of Specific Concern “New Insights into Microgravity and Space Biology” ( This report might be obtained on the web with no charge.


Cui Y, Liu W, Zhao S, Zhao Y, Dai J.

Advances in microgravity directed tissue engineering.

Adv Healthc Mater. 2023 Mar 9e2202768. Overview. On the web ahead of print.

Note: From the abstract: “Here, the present status, current advances, challenges, and prospects of microgravity associated to tissue engineering are reviewed.”


Ismaeel A, Van Pelt DW, Hettinger ZR, Fu X, Richards CI, Butterfield TA, Petrocelli JJ, Vechetti IJ, Confides AL, Drummond MJ, Dupont-Versteegden EE.

Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy.

Skelet Muscle. 2023 Mar 1013:six.

Note: Hindlimb unloading study.


Vilchinskaya N, Lim WF, Belova S, Roberts TC, Wood MJA, Lomonosova Y.

Investigating eEF2k/eEF2 pathway regulation and its function in protein synthesis impairment in the course of disuse-induced skeletal muscle atrophy.

Am J Pathol. 2023 Mar 3S0002-9440(23)00060-three. On the web ahead of print.


Wang Y, Liu H, Wei H, Wu C, Yuan F.

The impact of a knee brace on muscle forces in the course of single-leg landings at two heights.

Int J Environ Res Public Wellness. 2023 Mar 620(five):4652.

Note: From the abstract: “Single-leg landing is a single of the maneuvers that has been linked to non-make contact with anterior cruciate ligament (ACL) injuries, and wearing knee braces has been shown to lessen ACL injury incidence. The goal of this study was to decide whether or not wearing a knee brace has an impact on muscle force in the course of single-leg landings at two heights via musculoskeletal simulation.” This report might be obtained on the web with no charge.


Liu CJ, Yang X, Wang SH, Wu XT, Mao Y, Shi JW, Fan YB, Sun LW.

Stopping disused bone loss via inhibition of sophisticated glycation finish goods.

Int J Mol Sci. 2023 Mar 324(five):4953.

Note: This report is aspect of Section “Biochemistry” ( and might be obtained on the web with no charge.


Guez-Barber D, Colon LM, Raphael D, Wragan MA, Yun S, Eisch AJ.

Female and male microglia are not unique in the dentate gyrus of postnatal day ten mice.

Neuroscience Letters. 2023 Mar 8137171.

Note: From the abstract: “Microglia, the resident immune cells of the brain, assistance regular brain function and the brain’s response to illness and injury. The hippocampal dentate gyrus (DG) is an region of microglial study due to its central function in a lot of behavioral and cognitive functions. Interestingly, microglia and associated cells are distinct in female vs. male rodents, even in early life. Certainly, postnatal day (P)-dependent sex variations in quantity, density, and morphology of microglia have been reported in specific hippocampal subregions at certain ages. Having said that, sex variations in the DG have not but been assessed at P10, a rodent developmental time point translationally relevant to human term gestation. To address this know-how gap, Iba1+ cells in the DG (which are enriched in the Hilus and Molecular Layer) in female and male C57BL/6J mice had been analyzed for their quantity (by means of stereology) and density (by means of stereology and by means of sampling).”


Cariati I, Bonanni R, Rinaldi AM, Marini M, Iundusi R, Gasbarra E, Tancredi V, Tarantino U.

Recombinant irisin prevents cell death and mineralization defects induced by random positioning machine exposure in key cultures of human osteoblasts: A promising method for the osteoporosis therapy.

Front Physiol. 2023 Mar 1514:1107933.

Note: A random positioning machine was applied in this study.


Ge YX, Zhuang HJ, Zhang TW, Liang HF, Ding W, Zhou L, Dong ZR, Hu ZC, Chen Q, Dong J, Jiang LB, Yin XF.

Precise manipulation of circadian clock utilizing MnOtwo

 nanocapsules to amplify photodynamic therapy for osteosarcoma.

Mater Right now Bio. 2023 Apr19:100547.


Zhang P, Yan J, Liu Z, Zhou Q.

Impeded frontal-occipital communications in the course of Go/Nogo tasks in humans owing to mental workload.

Behav Brain Res. 2023 Feb 13438:114182.

Note: From the abstract: “Human brains rely on oscillatory coupling mechanisms for regulating access to prefrontal cognitive sources, dynamically communicating among the frontal and remote cortex. We be concerned that communications across cortical regions will be impeded when humans in intense space environments travel with mental load function, affecting the profitable completion of missions. Right here, we monitored crews of workers performing a Go/Nogo job in space travel, accompanied by acquisitions of electroencephalography (EEG) signals.”


Cavelli ML, Mao R, Findlay G, Driessen K, Bugnon T, Tononi G, Cirelli C.

Sleep/wake alterations in perturbational complexity in rats and mice.

iScience. 2023 Mar 1726(three):106186.

Note: From the abstract: “In humans, the level of consciousness is assessed by quantifying the spatiotemporal complexity of cortical responses utilizing Perturbational Complexity Index (PCI) and associated PCIst

 (st, state transitions). Right here, we validate PCIst

 in freely moving rats and mice by displaying that it is reduce in NREM sleep and slow wave anesthesia than in wake or REM sleep, as in humans.” This report might be obtained on the web with no charge.

Leave a Reply